Welcome to the Oxford Centre for Integrative Systems Biology website
OCISB: Towards understanding cellular signalling.
Biological function arises from the integration of processes interacting across a range of spatio-temporal scales. We aim to develop theoretical approaches which not only address problems at specific scales, but which bridge scales in a computationally efficient and mathematically tractable way. The approaches will be applied to a range of bacterial and eukaryotic sensory signalling networks, populated with data sets at different levels of completeness. The predictive models that we develop will be used to guide experiments, the results of which will be used to refine the models. This iteration between experiment and theory will both provide quantitative insights into important biological systems and enable the development of new tools with broad application.